Tobi kill s itachi s girlfriend. Mandara uchiha who also persudaed itachi to kill his family wrong in order to get the mangekyou u have to kill your best and madara was not his best friend becuz hes still alive.
While kisame would sometimes protest he considered itachi a good friend and would listen to his instructions.
Itachi's friend. He was of the uchiha clan of konohagakure and eventually became a konoha missing nin. Kisame is his friend in aketsuki and his friend from when he was younger was shisui. Itachi also had a decent partnership with his previous partner jūzō showing respect to him and after his death placing the remains of kubikiribōchō in jūzō s hand.
He was the best friend of shisui. The pair become unlikely friends during their academy days but itachi criticized her. He was a member of the akatsuki.
However when izumi met itachi after he saved her during the nine tails attack she fell for him. Itachi and tobi kills his clan uchiha. Itachi debuts in part i after hiruzen s death when he uses his infiltration of konoha to hunt down naruto uzumaki as an excuse to secretly check on sasuke s wellbeing.
He is the son of fugaku and mikoto uchiha. Itachi becomes good friends with his partner kisame hoshigaki who expresses concern for itachi s wellbeing.